A dehydrogenase is an enzyme belonging to the group of oxidoreductases that oxidizes a substrate by reducing an electron acceptor, usually NAD + /NADP +[1] or a flavin coenzyme such as FAD or FMN.

Dehydrogenase enzymes are specialised for a single activity, as their names suggest; however, they also show substrate promiscuity and accept many different substrates for reduction and oxidation.

Lactate Dehydrogenase (LDH) is widely distributed across many tissues, including the heart, liver, and skeletal muscle. The function of LDH is to interconvert pyruvate and lactate, a reaction important for regenerating NAD+ to keep glycolysis running in anaerobic conditions.

In yeast [40] and many bacteria, alcohol dehydrogenase plays an important part in fermentation: Pyruvate resulting from glycolysis is converted to acetaldehyde and carbon dioxide, and the acetaldehyde is then reduced to ethanol by an alcohol dehydrogenase called ADH1.

What are some common examples of dehydrogenases? Examples include lactate dehydrogenase (LDH), alcohol dehydrogenase (ADH), aldehyde dehydrogenases (ALDH), and isocitrate dehydrogenase (IDH). Each participates in distinct metabolic and biosynthetic pathways.

Dehydrogenases enzymes usually involve NAD+/NADH and are named for the substrate that is oxidized by NAD+. For instance in the reaction: ... which is used to regenerate NAD+ under anerobic conditions, the enzyme is named lactate dehydrogenase.

Serum lactate dehydrogenase (LDH) has been identified as a prognostic factor in extranodal lymphomas and should be obtained at baseline. Adequate liver, renal, and hematologic function should be established for patients who will be receiving chemotherapy.

A dehydrogenase enzyme is a type of oxidoreductase that facilitates the removal of hydrogen atoms (or hydride ions) from a substrate molecule, transferring them to an electron acceptor like NAD⁺ (nicotinamide adenine dinucleotide) or NADP⁺.

Pyruvate dehydrogenase, a multi-enzyme complex, links glycolysis to the Krebs cycle by converting pyruvate to acetyl-CoA, also generating NADH. Beyond energy production, dehydrogenases are involved in detoxification processes.

Lactate dehydrogenase, an oxidoreductase [EC 1.1.1.27] exists in different forms in different tissues possessing different subunits as a multi-enzyme complex called isoenzyme. It is the last enzyme of the glycolytic sequence or pathway essential for ATP generation.