In reviewing the information, the Committee will apply the following principles: Exposure or potential exposure is a key element; The information should be science-based, on the best available knowledge; The information should also be sufficiently detailed to enable the CRC to make an assessment.

“Bridging” is done when the notifying Party has used a risk evaluation from another country or international body as the basis for its national decision.

Bridging of assessments conducted with microbial pest control agents is only possible in very specific circumstances which are outlined here. * The general principles and procedures of bridging are described in this guidance document.

For some users, avoiding bridge exposure entirely through swap-based execution is becoming a rational strategy, not a compromise. For others, especially within DeFi, bridges remain indispensable.

A practical guide to GHS hazard classification for substances and mixtures, covering bridging principles, calculation methods and compliance best practices.

General guidance on how to conduct bridging of risk assessments has now been added to the Toolkit.

New Approach Methodologies (NAMs) provide tools for supporting both human and environmental risk assessment (HRA and ERA). This short review provides recent insights regarding the use of NAMs in ERA of food and feed chemicals.

For a hazard assessment, a common surrogate method is to delineate their hazard potential from data of individual ingredients. Another approach exists to extrapolate from mixtures with test data to nontested mixtures. Such bridging principles have been in use in certain sector-specific applications already in the past.

Utilizing this new methodology to represent natural hazard exposure alleviates the burden of complex computation. It allows exposure data to be more expeditiously integrated into research and indices relating to natural hazards.

To ensure accurate hazard classification without resorting to unnecessary testing, existing toxicity data of a relevant reference mixture should be applied to a similar mixture when technically justifiable.