Non-steroidal anti-inflammatory drugs or NSAIDs are some of the most commonly used medicines available. Experts say that taking NSAIDs for a short time at the lowest effective dose is generally safe.

Learn which common pain relievers are easiest on your liver, and how factors like alcohol use or liver disease can shift the safest choice for you.

Several non-narcotic options exist when it comes to pain management. Over-the-counter pain medications such as acetaminophen (Tylenol) and nonsteroidal anti-inflammatory drugs (NSAIDs) are safer. But they shouldn’t be taken long term due to a risk of side effects.

Learn about the differences between these popular OTC pain medications and which is best for headaches, fever, back pain and other conditions.

Compare risks and benefits of common medications used for Pain. Find the most popular drugs, view ratings and user reviews.

How can you get the relief you need and minimize your risk of side effects? Consumer Reports guides you to the safest ways to ease pain.

It’s best to stay away from, or minimize the use of, the over-the-counter painkillers that can make existing health conditions worse. For example, people who have liver problems or are heavy drinkers shouldn’t take acetaminophen (Tylenol), which can worsen those problems.

Here, we’ll cover the six of the best pain relievers you can find OTC and how they compare. 1. Ibuprofen (Advil) Ibuprofen is part of a group of medications called nonsteroidal anti-inflammatory drugs (NSAID). These medications treat pain, fever, and swelling.

Discover the best pain reliever for your needs. Compare options, safety tips, and expert advice for safe, effective relief.

Acetaminophen (Tylenol) is generally considered the safest over-the-counter pain reliever for most people, largely because it doesn’t carry the stomach bleeding and cardiovascular risks associated with NSAIDs like ibuprofen and naproxen.