Platelet-derived growth factor is a dimeric glycoprotein that can be composed of two A subunits (PDGF-AA), two B subunits (PDGF-BB), or one of each (PDGF-AB). PDGF [1][2] is a potent mitogen for cells of mesenchymal origin, including fibroblasts, smooth muscle cells and glial cells.

PDGF, or Platelet-Derived Growth Factor, is a protein found in platelets, the tiny cells in our blood responsible for healing and tissue regeneration. PDGF is one of several key growth factors released when platelets become activated in response to injury.

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We review basic aspects of the PDGF ligands and receptors, their developmental and pathological functions, principles of their pharmacological inhibition, and results using PDGF pathway-inhibitory or stimulatory drugs in preclinical and clinical contexts. Keywords: PDGF receptor, cancer, development, fibrosis, platelet-derived growth factor

Platelet‐Derived Growth Factor BB (PDGF) is a potent stimulator of tissue regeneration. It has received FDA approvals in four medical therapeutic indications for tissue regeneration.

PDGF is the product of two genes, PDGF A and B, which give rise to two distinct PDGF chains with 60% homology (97). PDGF exists as a homodimer or heterodimer of these two chains, which can combine to form PDGF AA, BB, and AB.

The PDGF family consists of PDGF-A, -B, -C and -D, which form either homo- or hetero dimers (PDGF-AA, -AB, -BB, -CC, -DD). The four PDGFs are inactive in their monomeric forms.

This family of VEGF-related growth factors consists of four members: PDGF-A, PDGF-B, PDGF-C, and PDGF-D, the homo- or heterodimers of which interact preferentially with one of the three known cellular RTKs, namely PDGFRα, PDGFRβ, and PDGFRγ, each endowed with different cellular functions.

Understand Platelet-Derived Growth Factor (PDGF) – from its core biological functions to its critical roles in health, disease, and medical therapies.

This review summarizes the physiologic activity of PDGF, the expression of PDGF during embryonal development, and the roles of PDGF expression in nonmalignant disease and different tumors.