Align-GVGD is a freely available, web-based program that combines the biophysical characteristics of amino acids and protein multiple sequence alignments to predict where missense substitutions in genes of interest fall in a spectrum from enriched delterious to enriched neutral.

The present review provides an update on the pathological, clinical, and genetic abnormalities associated with ARVC/D, focusing on the contribution of emerging imaging techniques and genetics for diagnosis.

Align-GVGD is a freely available, web-based program that combines the biophysical characteristics of amino acids and protein multiple sequence alignments to predict where missense substitutions in genes of interest fall in a spectrum from enriched delterious to enriched neutral.

Arrhythmogenic Right Ventricular Dysplasia / Cardiomyopathy (ARVDC), is a genetic condition that may cause ventricular tachycardia and sudden cardiac death in young individuals.

A-GVGD combines multiple sequence alignment of orthologous sequences with the Grantham distance to classify missense variants, i.e. to distinguish human disease susceptibility missense changes from changes of little clinical significance.

A-GVGD combines multiple sequence alignment of orthologous sequences with the Grantham distance to classify missense variants, i.e. to distinguish human disease susceptibility missense changes from changes of little clinical significance.

A-GVGD combines multiple sequence alignment of orthologous sequences with the Grantham distance to classify missense variants, i.e. to distinguish human disease susceptibility missense changes from changes of little clinical significance.

The R package {agvgd} provides an R implementation of the Align-GVGD 1, 2, 3 (A-GVGD) method. A-GVGD combines multiple sequence alignment of orthologous sequences with the Grantham distance 4 to classify missense variants, i.e. to distinguish human disease susceptibility missense changes from changes of little clinical significance.

A-GVGD combines multiple sequence alignment of orthologous sequences with the Grantham dis-tance to classify missense variants, i.e. to distinguish human disease susceptibility missense changes from changes of little clinical significance.

The R package agvgd provides an R implementation of the Align-GVGD 1, 2, 3 (A-GVGD) method. A-GVGD combines multiple sequence alignment of orthologous sequences with the Grantham distance 4 to classify missense variants, i.e. to distinguish human disease susceptibility missense changes from changes of little clinical significance.